Information
- Publication Type: Master Thesis
- Workgroup(s)/Project(s):
- Date: September 2015
- First Supervisor: Eduard Gröller
Abstract
Breast cancer is the second most common cancer death among women in developed
countries. In less developed countries it has a mortality rate of about 25% rendering it the most common cancer death. It has been demonstrated that an early breast cancer diagnosis significantly reduces the mortality. In addition to mammography and breast
ultrasound, Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is
the modality with the highest sensitivity for breast cancer detection. However, systems for automatic lesion analysis are scarce. This thesis proposes a method for lesion evaluation without the necessity of tumor segmentation. The observer has to define a Region Of Interest (ROI) covering the lesion in question and the proposed system performs an automated lesion inspection by computing its Fourier transform. Using the Fourier
transformed volume we compute the inertia tensor of its magnitude. Based on the gathered information, the Göttinger score, which is a common breast cancer analysis scheme, is computed and the features are presented in newly create plots. These plots
are evaluated with a survey where radiologists participated. The Göttinger score assigns a numeric value for the following features: shape, boundary, Internal Enhancement
Characteristics (IEC), Initial Signal Increase (ISI) and Post Initial Signal (PIS). We tested our method on 22 breast tumors (14 malignant and 8 benign ones). Subsequently, we compared our results to the classification of an experienced radiologist. The automatic
boundary classification has an accuracy of 0.818, the shape 0.773 and the IEC 0.886 compared to the radiologist’s results. An evaluation of the accuracy of the benign vs. malignant classification shows that the method has an accuracy of 0.682 for all
the Göttinger score features and 0.772 using only the shape, boundary and IEC. The evaluation of the plot shows that radiologist like the visual representation of the Göttinger
score for single lesions, they, however, refuse the plots where multiple lesions are presented
in one visual representation.
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BibTeX
@mastersthesis{Hirsch_Christian_2015_ABL,
title = "Automatic Breast Lesion Examination of DCE-MRI Data Based on
Fourier Analysis",
author = "Christian Hirsch",
year = "2015",
abstract = "Breast cancer is the second most common cancer death among
women in developed countries. In less developed countries it
has a mortality rate of about 25% rendering it the most
common cancer death. It has been demonstrated that an early
breast cancer diagnosis significantly reduces the mortality.
In addition to mammography and breast ultrasound, Dynamic
Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is
the modality with the highest sensitivity for breast cancer
detection. However, systems for automatic lesion analysis
are scarce. This thesis proposes a method for lesion
evaluation without the necessity of tumor segmentation. The
observer has to define a Region Of Interest (ROI) covering
the lesion in question and the proposed system performs an
automated lesion inspection by computing its Fourier
transform. Using the Fourier transformed volume we compute
the inertia tensor of its magnitude. Based on the gathered
information, the G\"{o}ttinger score, which is a common
breast cancer analysis scheme, is computed and the features
are presented in newly create plots. These plots are
evaluated with a survey where radiologists participated. The
G\"{o}ttinger score assigns a numeric value for the
following features: shape, boundary, Internal Enhancement
Characteristics (IEC), Initial Signal Increase (ISI) and
Post Initial Signal (PIS). We tested our method on 22 breast
tumors (14 malignant and 8 benign ones). Subsequently, we
compared our results to the classification of an experienced
radiologist. The automatic boundary classification has an
accuracy of 0.818, the shape 0.773 and the IEC 0.886
compared to the radiologist’s results. An evaluation of
the accuracy of the benign vs. malignant classification
shows that the method has an accuracy of 0.682 for all the
G\"{o}ttinger score features and 0.772 using only the shape,
boundary and IEC. The evaluation of the plot shows that
radiologist like the visual representation of the
G\"{o}ttinger score for single lesions, they, however,
refuse the plots where multiple lesions are presented in one
visual representation.",
month = sep,
address = "Favoritenstrasse 9-11/E193-02, A-1040 Vienna, Austria",
school = "Institute of Computer Graphics and Algorithms, Vienna
University of Technology ",
URL = "https://www.cg.tuwien.ac.at/research/publications/2015/Hirsch_Christian_2015_ABL/",
}